Dungeons of Dredmor is possibly not too well-liked by roguelike purists because it deviates from typical features in couple of points: first, it has graphics instead of pure ASCII art, and second, it has an available setting to remove permadeath, thus going to see big bad Dredmor is not an unreasonably difficult feat.
Otherwise the popular characteristics are there, the hero wanders in randomly generated dungeons, meeting random monsters and strange events, collecting random equipment and trying to get to lower and lower levels of the dungeon. And death comes, sometimes completely unfairly (though not quite as easily and frequently as in, say, Nethack)
Beside added graphics, almost everything in the game comes with zany names, visuals and flavour texts, often poking fun at fantasy cliches, so there is also a lot to see and read in the game. As often happens with comedy, it is probably not to everyone's taste but I was amused. There is also lots of customization available for character skills, and lots of parameters affected by skills and equipment (if you haven't hit a monster with ten different damage types simultaneously, you are still a beginner). Having all these things to see, it does make sense that the game is not quite as lethal as some other roguelikes, and eventually one probably wants to try that "no permadeath" option.
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